Ohio River
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Wikipedia page about the Ohio River
The Ohio River, which streams westward from Pittsburgh, Pennsylvania, to Cairo, Illinois, is the largest tributary, by volume, of the Mississippi River in the United States. At the confluence, the Ohio is even bigger than the Mississippi (Ohio at Cairo: 281,500 cu ft/s; Mississippi at Thebes: 208,200 cu ft/s and, thus, is hydrologically the main stream of the whole river system, including the Allegheny River further upstream.